Two sample MR report
PARK7_Monocyte (Mono) against finn-b-ASTHMA_ALLERG_EXMORE
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 6 | 1.0250622 | 2.5352878 | 0.7066644 |
| Weighted median | 6 | 0.1286819 | 0.0528166 | 0.0148346 |
| Inverse variance weighted | 6 | 0.1385488 | 0.0434879 | 0.0014430 |
| Simple mode | 6 | 0.1048569 | 0.0748605 | 0.2202077 |
| Weighted mode | 6 | 0.1048569 | 0.0783392 | 0.2383696 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 0.6066704 | 4 | 0.9623196 |
| Inverse variance weighted | 0.7289752 | 5 | 0.9813407 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.2722564 | 0.7784957 | 0.7441846 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 5.27e-05 | 0 | TRUE | 0.4922096 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
